Molecular Evaluation of Salicin against Gamma-Irradiation in Rats

The book represents experimental work. It is concerned with studying the ameliorative effect of salicin which was isolated from Egyptian willow leaves (Salix suberrata) against the mutagenic effect of irradiation on reproductive organs of both male and female rats. It shows the various abnormalities occurred as a result of irradiation in the different electrophoretic patterns including protein, lipoprotein and zymogram in the male and female reproductive tissues. This was in addition to the study at the molecular level which was represented by studying the genomic DNA fingerprinting in the male and female reproductive organs. The study was supported by showing irradiation effect on the antioxidant enzymes which were separated electrohoretically. The main objective of the study was to optimize salicin as a radioprotector against the mutagenic effect of irradiation on the male and female reproductive tissues in the hope that this compound may be suitable as antioxidative radioprotector to impress radiation-induced oxidative stress and various mutations in male and female rats.