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Multi-Step Synthesis of Solid Support with Protected 5'-Aminouridine
Angol
138 b
30 nap a termék visszaküldésére
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17 168
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During my M.S. thesis work I was involved in a§multistep synthesis of solid support bearing a§modified nucleoside for automated synthesis of§siRNAs. First, I developed a three-step synthesis of§protected 5''-amino uridine from uridine. Next I§prepared the 3''-succinate of 5''-amino uridine in a§one-pot two-step synthesis and attached it to a solid§support via a succinamide linker. I had analyzed and§characterized all new compounds using NMR techniques.§Others in our laboratory used this solid support for§synthesis of amide-modified siRNAs. We anticipate§that the amide linkages will facilitate crossing the§cellular membrane and improve nuclease resistance,§biodistribution and pharmacokinetics of modified siRNAs.
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Angol
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